Acmella mutisii is native to the Andean region of Colombia, where it is typically found at elevations ranging from approximately 6,500 to 11,000 feet. The species is a herbaceous perennial with an upright growth habit and is endemic to Colombia, meaning it is not naturally found outside the country. Its flowers are characterized by a compact, rounded central disc composed of bright yellow florets surrounded by a variable number of flattened yellow ray florets, often reduced and unevenly spaced.